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Hepatic G6PD enzymatic activity is diminished in G6PD-deficient individuals (93), can be altered in non-deficient individuals by exogenous factors, such as insulin and high fat diets (94, 95), and can be upregulated to meet increased demand in states of physiologic stress

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A volume of 5 l of each sample was loaded for metabolite detection

This is particularly valuable in regenerative medicine, where timely interventions can greatly influence recovery

In many neurological disorders, abnormal iron accumulation is one of the common features, although it remains debated whether iron is a driving cause or a consequence of the disease process (Levi et al., 2024)