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The rate varies significantly between individuals, but a general pattern emerges

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In some embodiments, the otic formulation or composition comprises between about 0.10% to about 2% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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The bioregulator approach to MS would involve supporting multiple organ systems simultaneously: the thymus for T cell regulation, the brain for neuroprotection, the pineal gland for melatonin-mediated immune balance, and the vasculature for BBB integrity