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As an excitatory neurotransmitter, high level of glutamate can alter the strength of certain groups of glutamatergic synapses in a variety of brain regions, such as the prefrontal cortex (PFC), hippocampus, and nucleus accumbens (NAc), causing dysfunction of cortico-mesolimbic reward circuitry that underlies many manifestations of depression (52)

Glutathione permeability of CFTR

10.1038/ncprheum0531 Nat Clin Pract Rheumatol

coli WT in the presence of 1 NF after each light exposure, where the ratio recovered slowly after the first light pulse but failed to recover after the second illumination cycle