The inhibition of serine and glycine bidirectional conversion by sertraline prior irradiation reduces the pool of nucleotides, as we previously observed, and concurrent and post-treatment with sertraline might hinder the synthesis of the antioxidant GSH and NADPH production, which exposes cancer cells to the accumulation of endogenous ROS and radiation-induced ROS causing severe oxidative stress [70]
Pro-oxidative means the creation of free radicals and reactive oxygen species (Hydrogen Peroxide) that have antibacterial, antiviral, and anti-neoplastic properties.
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In fact, this ratio is often used by scientists as a marker of cellular health and how much stress the body is under
A rate of increase of 1 fluorescence unit per minute on the recorder was calibrated to correspond to a rate of formation of conjugate of 0.1 nmoles ml -1 min -1
