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Clinical trials used once-weekly subcutaneous dosing with a gradual titration schedule spanning several weeks

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Tsao A, Lin H, Carter B, Lee JJ, Rice D, Vaporciyan AA, Swisher SG , Mehran R, Heymach J, Nilsson M, Youhong F, Nunez M, Diao L, Wang J, Fujimoto J, Wistuba I, Hong W

As mentioned previously, inflammation can induce myocardial hypertrophy and fibrosis during cardiac injury, destroy BBB and lead to neurological defects in the ischemic region, promoting the progress of CCVDs

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