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It is noteworthy that this superior effectiveness extended to primates (humans and cynomolgus monkeys) and rodent models of obesity and diabetes, such as db/db (diabetic) mice and Zucker diabetic fatty (ZDF) rat

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RASSF1 is a tumor suppressor gene where hypermethylation of the promoter in eutopic and ectopic tissue with endometriosis could mediate RASSF1 downregulation and cell proliferation/apoptosis [90, 91]

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