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The evaluation by the physician should include an assessment for possible complications of GERD based on the presence of such symptoms or findings as: Cough Asthma Hoarseness Sore throat Difficulty swallowing Unexplained lung infections Anemia (due to bleeding from esophageal inflammation or ulceration) Clues to the presence of diseases that may mimic GERD, such as gastric or duodenal ulcers and esophageal motility disorders, should be sought

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A land use mix measure (factor 3) was calculated based on entropy [66] following an approach described by Donnellan [67], whereby land use zoning data provided by councils were re-classified into the following six categories: commercial, residential, retail/industrial, institutional, open space, and other (e.g., vacant land)

The risk of myocardial infarction is dose-dependent

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