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The incorporation of functional linkers containing disulfide bonds, diselenide bonds, or azo bonds enables the construction of stimuli-responsive drug delivery systems that react to high GSH levels or hypoxic conditions, improving targeting and control over therapeutic release (156, 157)

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In recent years, ferroptosis has emerged as a promising target for countering highly aggressive malignancies, and is an iron-dependent form of regulated cell death associated with accumulation of reactive oxygen species (ROS) and increased lipid peroxidation 7

The emerging role of non-coding RNAs in the epigenetic regulation of pediatric cancers