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During microneedling, the dermis, or lower layers of skin, is punctured through the epidermis, or top layer of skin, using incredibly tiny needles

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For example, in the male reproductive system, melatonin can inhibit the expression of key steroidogenic genes (such as p450scc, p450c17, and StAR) in Leydig cells via MT1 receptors, thereby reducing testosterone synthesis (66) to inhibit sexual maturation, spontaneous ovulation, and the estrous response (67)

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Benoff S, Hauser R, Marmar JL, et al