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In addition, the accumulation of female mouse germline mtDNA mutations exacerbates ovarian aging and reduces lifespan (Ross et al., 2014

Cyclin dependent kinase 4 and 6 (chemical messengers) are downstream of signaling pathways which lead to the proliferation of cells

Ultrathin (~70 nm) sections were obtained using Leica EM UC6 Ultramicrotome (Leica, Germany) attached with diamond knife (DiATOME, Switzerland) and double-stained with 1.5% uranyl acetate (15 min at 37 C) followed by 3% lead citrate for 4 min

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He noted that follicular "miniaturization" (the shrinking of follicles seen in pattern baldness) could potentially be reversed by these peptides