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BH4, which is derived from its precursor GTP via three enzymatic reactions catalyzed by GCH1, 6-pyruboyl tetrahydrobiopterin synthase and sepiapterin reductase, exhibits robust antioxidant activity both in vivo and in vitro, directly protecting cells from lipid peroxidation

Mar Drugs 18(7):357

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PD The degeneration of dopaminergic neurons in PD is fueled by iron overload, mitochondrial dysfunction and oxidative stress, all of which are tightly linked to ferroptosis

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