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In conclusion, more detailed comprehensive pharmacodynamic and pharmacokinetic researches are extremely necessary in the future, as well as further clinical trials to confirm the efficacy and safety of these therapeutic herbal preparations, extracts and compounds

Perspective: Risks/adverse events for epidural spinal injections

Elevated serum levels of specific metabolites, such as B-cell activating factor, along with increased intestinal permeability and inflammation, further suggest the link between microbial dysbiosis and immune dysregulation [139, 140] ( Figure 5 )

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