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HGF/Met targeting strategies Preclinical studies On the basis of the understanding of HGF/Met signaling and its role in carcinogenesis, metastasis and resistance to several therapeutic approaches, a large number of agents have been developed to target this signaling axis

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Researchers can reconstitute a peptide vial, use portions of it across multiple laboratory sessions over 2-4 weeks, and maintain reasonable confidence that the vial has not become microbially compromised between sessions

Key molecular features include the F23 Cagri residue anchoring the peptide at the receptor transmembrane (TM) bundle level and the micelle, an E14-R17 intramolecular salt bridge enhancing helical stability, and C-terminal P37 Cagri interaction with the receptor ECD