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Clinical trials combining these agents reported 35-40% discontinuation rates when both were dosed together

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Important Safety Information Who should not use tirzepatide: Type 1 diabetes patients (tirzepatide is not approved for type 1 diabetes) History of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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In addition to addressing genetic knowledge gaps in diverse populations, our fundamental knowledge of T1D progression is limited by the current reliance on animal models, which poses key translational limitations for human pathogenesis