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Agm antidepressant effects have been reported to depend upon both imidazoline and GABA receptors, and NMDA-NO axis inhibition (and less consistently between studies, perhaps also serotonin and adrenergic receptors), suggesting a complex ketamine-like rapid antidepressant mechanism that may involve Agm/Glu co-transmission (Uzbay, 2012

Practical notes: most studies use ubiquinone, co-administer with dietary fat, and review potential interactions, especially with lipid-lowering therapy

These overlapping effects likely produce additive rather than synergistic benefits in specific pathway components

(m)-(n) H&E staining results of excised tumor margin, Scar bar: 200 m

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