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Further studies are thus warranted to determine the role of disrupted glutathione homeostasis in disease initiation and progression

Safety for both CBD and NAC at the 300 mg and 2000 mg respectively is very strong

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Disruption of this integrated network (e.g., via ferroptosis inhibitors targeting ACSL4/GPX4, anti-inflammatory agents blocking HMGB1/IL-33, or HIF modulators balancing hypoxia adaptation) can break the pathogenic cycle, highlighting the therapeutic potential of targeting the networks central nodes rather than individual pathways