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While glutathione and collagen are generally considered safe, individual needs may vary

2014 Jan 10;533(2):469-76

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Larger trials are needed to ensure that curcumin can be safely used with conventional UC treatments and to further support its potential therapeutic benefits for relapsing-remitting UC

Several enzymes involved in the glutathione pathway, such as -glutamylcysteine synthetase (GCLC), glutathione synthetase (GSS), glutathione peroxidase 4 (GPX4), and glutathione reductase (GSR), are regulated, at least in part, by Nrf2 through its activation of the Nrf2-antioxidant response element