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doi: 10.1016/j.jaci.2011.09.041

The study conclusively proved that the 40:1 ratio was statistically the most effective formulation for restoring ovulation, normalizing basal insulin levels, and reducing free testosterone, whereas higher doses of D-chiro-inositol resulted in decreased activity and were less effective

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Statistical analysis Data from clinical, cell culture, and mouse studies were analyzed using regression analyses and ANOVA with Sigma Stat software (SPSS, Chicago, IL)