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2026 May 2

While it is generally unclear whether toxicity from e-cigarettes stems from higher nicotine concentrations or rapid delivery mechanisms, it is hypothesized that increased plasma concentration and higher bioavailability of nicotine, depending on the isomer of nicotine, make it faster to be absorbed into circulation, hence why its effects may be exaggerated

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Over the past three decades, many countries have used school-based interventions to prevent adolescents smoking (37) as this environment offers efficient and equitable access to adolescents, where behavioural change activities can be integrated into school curriculums (3842)