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Influence of gene polymorphisms on vitiligo patients Several gene polymorphisms have been considered potential risk factors in the development of vitiligo, regardless of the type of disease (chemical-induced or idiopathic) in the search of an association between genotype and symptom

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Additionally, caspase-8 regulates pyroptosis under specific conditions: nucleus-localised PD-L1 induces pyroptosis via caspase-8-mediated cleavage of GSDMC in the hypoxic tumour microenvironment [69]