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Symptoms associated with exposure to inappropriate endotoxin levels may include fever, chills, myalgia (muscle pain), headache, nausea, vomiting, hypotension (low blood pressure), shock and death

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The present review thus focuses on the role of GPX4 in the myeloid lineage, describing how increase in GPX4 expression can impact on myeloid cell homeostasis and transformation and whether GPX4 inhibition could represent an attractive strategy to treat AML patients