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CDS is characterized by excessive accumulation of TAG in the cells of many organs, and the clinical manifestations include ichthyosis, cataracts, ataxia, neurosensory hearing loss, and mental retardation (67)

(6) neurotrophic agents offer the ability to facilitate synaptogenesis, neurogenesis and neuroprotection thus greater research attention must be directed toward creating small molecule analogs designed to penetrate the BBB and activate these brain systems

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Cartilage restoration procedures have typically avoided small-size defects ( 35, partial meniscectomy, ligamentous instability, malalignment) are related to mechanical comorbidities that current treatments do not address

Clancy, R., Cederbaum, A