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Chronic stress triggers the release of cortisol, the body's primary stress hormone

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BPC-157 activates the VEGFR2-Akt-eNOS pathway, increasing blood vessel formation by 129% to 152% in damaged tissues according to preclinical studies

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Cannabis affects sleep architecture too, and although the data is less robust than for alcohol, the principle is the same: anything that flattens slow-wave sleep flattens your response