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Primary fragment screening by LO-NMR Whilst the XChem screen highlighted the possibility of obtaining hit matter in the TIN2 TBM leucine pocket of TRF1 TRFH , it also raised questions about the tractability of the fragment hits obtained using the available crystal system, especially given the crystal contacts and poor hit confirmation rate by the orthogonal CPMG assay

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Het peptide lijkt in diermodellen in te grijpen op neurotransmittersystemen , beschermt de lever tegen toxische stoffen en moduleert de reactie op alcohol en ontstekingsremmers

Nat Med 31 , 819828 (2025)