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The increased serum levels of bilirubin conjugates result in the spontaneous (nonenzymatic) transesterification of bilirubin glucuronide with an amino group on albumin, producing a covalent bond between albumin and bilirubin

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U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy