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Konopleva M, Tari A, Estrov Z, Harris D, Lopez-Berestein G, Andreeff M

& van Esch, J

The authors of this study also found that supplementing zinc deficient animals with methyl donors during IVM restored histone H3K4 and increased IVF success rates (87)

Genetically modified folate overproducing strains of some fungi and bacteria have been constructed, e.g., Ashbya gossypii , Escherichia coli , and Bacillus subtilis , the first being the best folate producer reported to date with folate titers of 6.6 mg/L (i.e., 146-fold higher than the wild strain) 631,632,633,634

The peptide backbone provides three coordination sites for copper: the free alpha-amino group of glycine, the deprotonated amide nitrogen of the glycyl-histidyl bond, and the imidazole nitrogen of the histidine side chain, with the lysine epsilon-amine remaining available for further interactions