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Hypofiltration was defined as eGFR 140mmHg) (p 185 mmHg) at randomisation

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Moreover, such endogenous brain proteins, cross-seeded to induce aggregation into toxic oligomers, could become the pernicious species responsible for growth of slowly expanding lesions in progressive MS, or form tiny islands of deposited seed to which microglia react to form nodules in pre-lesions