Diabetes-induced ROS drives the thickening of the glomerular basement membrane, mesangial dilation, accumulation of extracellular matrix, glomerular sclerosis, and abnormal renal hemodynamics [112]
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During the past 20 years, numerous additional roles have been defined for this tissue, including the regulation of vascular tone, modulation of inflammation, promotion, as well as inhibition of vascular growth and modulation of platelet aggregation and coagulation