The compound targets the Sec residue of the Gly-Cys-Sec-Gly active site motif of the human TrxR and irreversibly inhibits the enzyme (Duan et al., 2014)
Histological assays showed a lack of severe immune-cell infiltration in the liver of hepsin / mice compared to wild-type mice within 6 h post-APAP exposure, suggesting the need for further investigation of inflammation in hepsin-mediated APAP intoxication
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rea cardiometablica: potenciales efectos y cautelas Se han publicado anlisis en contextos cardiolgicos (por ejemplo, tras infarto agudo), donde se observan asociaciones con mejoras en algunos desenlaces
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