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In our study, we used higher concentration of TA (500 mg/5 ml) and observed that on right cheek, there was significant reduction in VAS score from baseline to 8th week and baseline to 12th week, suggesting that TA was more effective in treatment of facial melasma

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If someone is experiencing this side effect, any resulting weight loss is a symptom of a much larger mental health concern that needs immediate attention from their prescribing doctor

A rejection, delay, label limitation, or additional trial requirement would also matter