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It also demonstrates beneficial pharmacological impacts on the cardiovascular, central nervous, and immune systems ( Eleutherococcus senticosus are rich in active metabolites, such as eleutheroside B, eleutheroside E, and isofraxidin, which regulate multiple targets that are involved in antioxidant damage, anti-inflammatory effects, neurotransmitter modulation, improvement of neuronal growth, and anti-apoptosis, thereby demonstrating unique potential in the prevention and treatment of neurological diseases and high-altitude illnesses ( In vivo experimental research has revealed that eleutheroside B can significantly inhibit the abnormal activation of the JAK2/STAT3 signaling pathway in a rat model of HACE, and thereby reduce oxidative stress damage and suppress the neuroinflammatory cascade

[DOI] [PubMed] [Google Scholar] 14.Bartlett MG, Gourley GR

Blagg, J