4.1 Clinical relevance of the CLP model The CLP model was selected for its unique ability to recapitulate core clinical features of SAE: polymicrobial sepsis, hippocampal neurodegeneration, and chronic cognitive impairment ( 4.2 Microglia-mediated oxidative neuronal injury Microglial activation initiates neuronal damage, and a previous study revealed that the microglial inhibitor minocycline reduces neuronal apoptosis ( in vivo oxidative stress ( Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage
The fruits are consumed dried or marinated in sugar or honey to make jam, syrup, juice, or compote
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Potential Clinical Applications Although clinical adoption remains limited, researchers have explored potential applications in: diabetic wound management surgical recovery skin graft healing Future clinical trials will be necessary to determine whether these experimental findings translate into routine medical therapies
Allergic Reactions : Though rare, some users report skin rashes, itching, or swelling
