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Los telmeros se acortan con cada divisin celular a lo largo de la vida un proceso que eventualmente conduce a la senescencia celular (la clula deja de dividirse) o a la apoptosis (la clula muere) cuando los telmeros se vuelven crticamente cortos

d-i , Autochthonous tumors from MMTV-PyMT Gclc f/f Rosa26-CreERT2 mice were excised and orthotopically transplanted into the mammary gland or subcutaneously transplanted into the flank of wild-type C57BL/6 mice, which were treated with vehicle (corn oil