Glossary T2D Type 2 diabetes scRNA-seq Single-cell RNA sequencing ER Endoplasmic reticulum scATAC-seq Single-cell sequencing assay for transposase-accessible chromatin NGPs Next-generation probiotics GLP-1 Glucagon-like peptide-1 GLP1R Glucagon-like peptide-1 receptor GIPR Glucose-dependent insulinotropic polypeptide receptor mRNA Messenger RNA cCREs Candidate cis-regulatory elements snRNA-seq Single nucleus RNA sequencing MODY3 Maturity-onset diabetes of the young, type 3 STZ Streptozotocin FAK Focal adhesion kinase PNM factors PDX1, NGN3 and MAFA EECs Enteroendocrine cells T1D Type 1 diabetes AAb + Autoantibody-positive NK Natural killer TFs Transcription factors DEGs Differentially expressed genes SNPs Single nucleotide polymorphisms HPAP Human Pancreas Analysis Program WGBS Whole-genome bisulfite sequencing UPR Unfolded protein response DARs Differentially accessible chromatin regions HiChIP High-throughput chromatin conformation capture with immuno precipitation SCFAs Short-chain fatty acids GPCRs G-protein-coupled receptors Treg Regulatory T cells LPS Lipopolysaccharides FMT Fecal microbiota transplantation CFU Colony-forming unit HFD High-fat diet FBG Fasting blood glucose DPP-4 Dipeptidyl peptidase-4 ESCs Embryonic stem cells iPSCs Induced pluripotent stem cells References 1 AldousN.MoinA
doi:10.1054/ghir.1999.9998 Compliance Statement This product is intended for laboratory research use only and is not approved for human or veterinary use
During fasting with decreased intra-portal insulin levels, hepatic GH sensitivity decreases leading to decreased serum IGF-I levels despite a compensatory increase in GH secretion
doi: 10.1186/s12967-021-02724-6
View Source Endocrinology Synergistic effects of growth hormonereleasing peptide and growth hormonereleasing hormone 1990 DOI: 10.1210/endo-127-6-3093 PMID: 2123433 Bowers CY, Reynolds GA, Durham D, Barrera CM, Pezzoli SS, Thorner MO View Source The Journal of clinical endocrinology and metabolism Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults 2006 DOI: 10.1210/jc.2005-1536 PMID: 16352683 Teichman SL, Neale A, Lawrence B, et al
