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Because they are both hydrogen-bond acceptors (the carbonyl C = O) and hydrogen-bond donors (the hydroxyl OH), they also participate in hydrogen bonding

NAD+ is a coenzyme that participates directly in over 500 enzymatic reactions in the body, playing a crucial role in energy metabolism and cellular processes

For mild-to-moderate severity methemoglobinemia in a patient who is stable , IV vitamin C could be an attractive option with meticulous observation of serial methemoglobin levels and escalation to more aggressive therapies (e.g., methylene blue) if needed

Int J Cancer 118(1):129138 Kuhn C et al (2016) Regulatory mechanisms of immune tolerance in type 1 diabetes and their failures

They require proper technique, clean supplies, and comfort with needles