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Rutgers M, van Pelt MJ, Dhert WJ, Creemers LB, Saris DB

Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimers disease

Acta neuropathologica 1991;81, 591596

Recent advances in neuroimaging technology allowing for in vivo quantification of GSH levels in the brain have shown decreased GSH in patients with MS compared to healthy controls, with the degree of depletion correlating with disease severity and showing parallel longitudinal decline over time (Mandal et al., 2015)

Future research must therefore focus on identifying markers capable of specifically crossing the BBB and on developing ultrasensitive technologies for reliable peripheral detection