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The peptide bond forms when a condensation reaction occurs between one amino acid's carboxyl group and another's amino group, which releases a water molecule

This differential processing of APP is determined by the cellular localization of each secretase, with -secretases predominantly expressed on the cell surface, whereas and -secretases mostly localize in the acidic environment of the endolysosome system (Zhang and Song, 2013)

IHC staining and western blotting confirmed reduced GGCT expression in siGGCT group (Fig

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