Adipose tissue has almost as much water in it as other tissues, so that the apparent total volume of distribution of theophylline is proportional to body weight even in obese patients
During the healing process, any part of the normal lining of stratified squamous epithelium in the distal oesophagus is replaced by a metaplastic simple columnar epithelium with mucin secreting goblet cells, also called specialised intestinal metaplasia (SIM)
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However, the evidence is limited, and results from one proprietary formulation cannot automatically be applied to every spray, lozenge or liquid product
Think of it like working with a personal trainer