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Cutsem EV, Cuyle PJ, Huijberts S, Yaeger R, Schellens JHM, Elez E, Tabernero J, Fakih M, Montagut C, Peeters M, Desai J, Yoshino T, Ciardiello F, Wasan HS, Kopetz S , Maharry K, Christy-Bittel J, Gollerkeri A, Grothey A
It should be noted that these fluorescence-based biodistribution studies provide qualitative and semi-quantitative information on local retention and tissue distribution rather than quantitative pharmacokinetic data, and no conclusions regarding systemic absorption or clearance kinetics were drawn from these experiments [34]
Acute injuries typically require one complete cycle
While the latter two have been substantiated with in vitro work 133,134 , clinical efficacy has been documented for the treatment of corneal disorders with UVA-activated riboflavin, resulting in its incorporation in routine ophthalmologic procedures 135