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While highly effective in reducing LDL, the cost of PCSK9 inhibitors severely limits their use, but they are expected to become more affordable with time

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Metabolic unpredictability: Simultaneously altering multiple metabolic pathways incretin signalling, glucagon activity, and NAD+ metabolism without clinical oversight introduces unpredictable physiological consequences

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Avoiding gut irritants: Reducing the intake of foods and substances that irritate the gut, such as alcohol, caffeine, and certain medications, can help maintain a healthy gut lining