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Other possible mechanisms include the accumulation of Fas(Nam et al., 2007), downregulation of cyclooxygenase-2 (COX-2), and caspase-3 activation (Liu et al., 2007)

The reduced activity of antioxidant enzymes in the body results in DNA hydroxylation, protein denaturation, increased lipid peroxidation, and impairment of cellular functions, disrupting the conditions necessary for cell survival