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134 The NLRP3 is also upregulated resulting from activated NF-B, and activates caspase 1 which induces cell pyroptosis, a type of programmed cell death characterized by the formation of pores in the plasma membrane, leading to the release of proinflammatory cytokines and subsequent cell lysis 38,135 (Fig

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PGN-EDO51, an enhanced delivery oligonucleotide (EDO) for the treatment of duchenne muscular dystrophy (DMD): results of a phase 1 study in healthy volunteers (P3-8.004)