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It became fashionable among the aristocracy and intellectual elite, who would gather in coffeehouses and salons to discuss politics, philosophy, and literature while enjoying their pipes

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Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions

They also were less likely to use other tobacco products except for e-cigarettes, nearly 27% compared with 20%, the study says