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10.1016/j.joca.2003.09.016 23 BurrD

Beyond primary mitochondrial disorders, in liver mitochondria, MT localizes to the intermembrane space and can be imported into the organelle, where its N-terminal -domain delivers zinc to the electron transport chain, inhibiting respiration in a tissue-specific and zinc-dependent manner

Low CuCl 2 concentrations (0.2-0.2.4mmol/l) did not induce significant differences, while higher concentrations (0.61.6.0mmol/l) led to significant toxicity in HepG2 ATP7B-KO cells (Fig