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224,607 This structure reveals at least seven inner sphere Co II coordination bonds with nucleobase nitrogen atoms, while the supramolecular chemistry of the folded RNA drives a cooperative metal binding that must contribute to fine-tuning of the regulatory response to these metals in cells

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Concurrent use of medications that affect b12 absorption Several common medications interfere with b12 absorption through various mechanisms

From an immunological perspective, these associations arise from a breakdown in self-tolerance mediated by overlapping T-cell and B-cell autoreactivity, shared cytokine pathways (e.g., IFN-, IL-18), and common antigen-presenting HLA alleles