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Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores

Chuck Schumer (DN.Y.) tells cameras

(Look for language like "US Tax Exempt", "Not for Sale in the U.S.," "Made for sale outside of U.S.," or "Made for sale in [Country X].") [ ] Yes (please write in the language on pack) [ ] No This could be on the front of the pack, a side panel, or somewhere else on the pack (e.g., tear tape) 11

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