The nonenzymatic functions of GSTs involve their interactions with cellular proteins, such as, Jun N-terminal kinase,(JNK), tumor necrosis factor receptor-associated factor-2 (TRAF2), apoptosis-signal-regulating kinase 1 (ASK), serine/threonine kinases (PKA, PKC), and tissue transglutaminase 2 (TGM2), during which, either the interacting protein partner undergoes functional alteration or the GST protein itself is post-translationally modified and/or functionally altered [53], [74]
Yang H, Villani RM, Wang H, Simpson MJ, Roberts MS, Tang M, et al
While it appears to have a gentler profile than traditional hypnotics, the long-term effects of exogenous administration, its exact metabolic fate, and potential for interaction with complex neuroendocrine disorders remain unknown outside of controlled research settings
Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions
1995 Dec;29(12):1263-73.