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Hoffman-La Roche Ltd Basel, Switzerland This article was underwritten, in part, by a grant from Bayer Consumer Care AG, Basel, Switzerland

In some embodiments, a formulation described herein, further comprises a gelling agent (e.g., poloxamer 407) and provides release of the therapeutic agent over a period of from about 1 day to about 3 days

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Following iFSP1 treatment, the sensitivity of tumor cells to ferroptosis was obviously enhanced, suggesting a new strategy for tumor treatment