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Increased HIF-1 activity is also observed for other iron chelators, such as salicylaldehyde isonicotinoyl hydrazone (SIH) and deferiprone ( FIGURE 11 Among the DFO analogs are those where the DFO molecule has been attached to various high-molecular weight polymers, including cellulose, dextran, or hydroxyethyl starch

PMID: 20 BeumerJCleversH

These mechanisms have been observed in various cancers, including breast, prostate, and colorectal cancer, highlighting CURs potential as an adjunct to conventional cancer therapies

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