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343 Reduced astrocytic homoeostatic support is also evidenced by the loss of endfeet polarisation of AQP4 344 and decreased expression of monocarboxylate transporter 1 345 responsive for lactate supply of neurones

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419,420 Mitochondrial iron accumulation, energy imbalance, increased ROS, and lipid peroxidation are all related to the pathogenesis of this disease, suggesting that ferroptosis may be closely related to Friedreichs Ataxia

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